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Localized drug delivery strategies could greatly benefit patients with peripheral nerve injury and could be easy for surgeons to implement. We developed a local drug delivery system (DDS) using drug‐loaded poly(lactic‐co‐glycolic acid) (PLGA) microspheres (MS) embedded in a fibrin gel. In an in vitro study, we investigated the biocompatibility of this DDS by performing a toxicity assay in which we...
The majority of bioengineering strategies to promote peripheral nerve regeneration after injury have focused on therapies to bridge large nerve defects while fewer therapies are being developed to treat other nerve injuries, such as nerve transection. We constructed delivery systems using fibrin gels containing either free GDNF or polylactide–glycolic acid (PLGA) microspheres with GDNF to treat delayed...
Introduction: Delays in surgical repair following nerve transection produce progressively inferior motor nerve regeneration. Regeneration can be improved with delivery of exogenous growth factor. We developed a delivery system that could be applied at the nerve repair site to deliver growth factors locally to regenerating nerve. Methods: Poly(lactic‐co‐glycolic acid) microspheres containing glial‐derived...
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