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An important consideration in developing physical biomimetic cell-stimulating cues is that the in vivo extracellular milieu includes nanoscale topographic interfaces. We investigated nanoscale topography regulation of cell functions using human fetal osteoblastic (hFOB) cell culture on poly(l-lactic acid) and polystyrene (50/50 w/w) demixed nanoscale pit textures (14, 29, and 45nm deep pits). Secondary...
Mechanical stimulation of osteoblasts by fluid flow promotes a variety of pro-differentiation effects and improving the efficiency of these mechanical signals could encourage specific differentiation pathways. One way this could be accomplished is by altering mechanical properties of osteoblasts. In this study, murine osteoblastic MC3T3-E1 cells were cultured on surfaces covered with nanometer-sized...
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