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Tropomyosin (Tpm) is an α‐helical coiled‐coil actin‐binding protein playing an essential role in the regulation of muscle contraction. The middle part of the Tpm molecule has some specific features, such as the presence of noncanonical residues as well as a substantial gap at the interhelical interface, which are believed to destabilize a coiled‐coil and impart structural flexibility to this part...
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