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A distinct structural feature of Plasmodium falciparum enolase (Pfeno) is the presence of a five amino acid insert ‐104EWGWS108‐ that is not found in host enolases. Its conservation among apicomplexan enolases has raised the possibility of its involvement in some important physiological function(s). Deletion of this sequence is known to lower kcat/Km, increase Ka for Mg(II) and convert dimer into...
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