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A series of benzothiazole based lipids (1–10) containing different derivatives of benzothiazole in the head group region were synthesized to determine the structure–activity relationship for gene delivery. The liposomes formulated were mixed with plasmid DNA encoding green fluorescent protein (α5GFP) or β-galactosidase (pCMV-SPORT-β-gal) and transfected into B16F10 (Human melanoma cancer cells), CHO...
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