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A sequential injection analysis (SIA) method for the assay of promethazine hydrochloride, based on its oxidation by acidified cerium(IV), was optimized. Three chemometric approaches were applied: (i) factorial design (3 3 applied to surface plot and 2 3 applied to effect factor) for screening the potential interacting variables, (ii) univariant for optimizing insignificantly interacting...
A simple and rapid differential electrolytic potentiometric titration method for the determination of ciprofloxacin was developed. The work is based on the fast complexation reaction between iron(III) and ciprofloxacin in a ratio of 1:3, respectively, in sulfuric acid media of 0.09 mol dm -3 . Among the electrodes tested silver amalgam electrodes were found to be a suitable indicating...
For the first time, promethazine hydrochloride chemiluminescence emission was monitored. The paper describes a new, specific and highly sensitive flow injection (FI) method for the determination of promethazine hydrochloride using both a peristaltic and a syringe pump. The method was based on the chemiluminescence emission intensity produced as a result of its oxidation reaction with permanganate...
For the first time, differential electropotentiometry (DEP) is coupled with the flow injection analysis (FIA) technique for detection of oxidation-reduction reactions, and is utilized for quantitative determination of vitamin C in pharmaceutical preparations using 1.0x10 -3 -M cerium(IV) in 0.50-M sulfuric acid as carrier. Two similar platinum electrodes were employed and polarized by...
For the first time electron spin resonance (ESR) spectroscopic technique has been used for a highly selective determination of chlorpromazine. The method is based on the oxidation reaction of chlorpromazine with cerium(IV) in sulfuric acid media. In this method 3.8x10 -3 mol dm -3 cerium(IV) was used in 0.035 mol dm -3 sulfuric acid with the ESR spectra recorded...
A sequential injection spectrophotmetric method for the assay of bromazepam anxiolytic drug has been reported. The method is based on the complexation reaction of bromazepam with iron(II) in hydrochloric acid media and spectrophotometrically measuring the product at λ max =585 nm. A comprehensive chemometrical optimization treatment was successfully utilized for determining the proper optimum...
An accurate selective flow injection chemiluminescence (CL) method for the assay of perphenazine was explored. In the method 394 ppm permanganate solution was used as a chemiluminogenic reagent in 0.289 mol dm -3 sulphuric acid media. A photomultiplier tube was used as a detector at a total flow rate of 4.94 ml/min. Perphenazine was determined by a linear calibration plot of the following...
A flow injection method for the assay of perphenazine using cerium(IV) as oxidant in a sulphuric acid media was adopted. Different chemometric techniques, considered the main objective of this work, were utilised to optimise sensitivity and sample throughput as a function of five experimental variables. The optimum conditions obtained by the super modified simplex method were, 0.170 M sulphuric acid,...
A sequential injection (SI) spectrophotometric method for the determination of oxprenolol in pharmaceutical products was developed. The method is based on the oxidation of oxprenolol on-line with Ce(IV) in sulfuric acid medium and the subsequent monitoring of the absorbance of the oxidized form of the drug at 480 nm. The procedure was optimized by the orthogonal array design at two and four levels...
A simple, sensitive and fairly rapid method for the determination of noscapine is described, based on the measurement of the absorbance of the organic soluble ion-association complex formed between the noscapine monocation and a bulky counter anion. Methyl Orange, Bromothymol Blue and Bromocresol Green (BCG) were examined as counter ions. The effect of few solvents, the counter-ion concentration...
A sequential injection spectrophotometric method for stoichiometric studies, optimization and quantitative determination of ciprofloxacin and norfloxacin was developed. The work is based on the complexation reaction of ciprofloxacin and norfloxacin with iron(III) in sulfuric acid media and a spectrophotometric measurement of absorbances of the corresponding complexes at 447 and 430 nm respectively...
An accurate high performance liquid chromatography method for the separation and quantification of a solution mixture of nitrazepam, diazepam and medazepam and medazepam was developed. The modified simplex program has been utilized for the optimization of the chemical and chromatographic parameters using the chromatographic response function as the quality criterion and a photodiode array as a detector...
A reasonably sensitive and highly selective spectrophotometric method for the determination of mercury(II) is proposed. The method is based on the extraction of the ion-associate formed by a mercury(II) thiacrown ether cationic complex with Bromocresol Green as the anionic counter-ion using chloroform as the extracting solvent. The effect of thiacrown ethers of different cavity sizes, namely 1,4,7,10,13-pentathiacyclopentadecane...
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