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The effect quantum dots have on primary rat macrophages is investigated, and the findings are compared to in vivo data. In vitro uptake kinetics and degradation both reflect in vivo findings; therefore, primary macrophages are shown to be an appropriate system with which to investigate cellular responses to quantum dots and other nanoparticles in order to guide in vivo studies.
Nanotoxicology is emerging as an important subdiscipline of nanotechnology. Nanotoxicology refers to the study of the interactions of nanostructures with biological systems with an emphasis on elucidating the relationship between the physical and chemical properties (e.g. size, shape, surface chemistry, composition, and aggregation) of nanostructures with induction of toxic biological responses. In...
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