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Fluid flow in paper is currently limited by capillary forces. Here we show how capillary flow control can be improved by integrating paper sectors in lab-on-a-disc platforms. To this end we combine the rotationally controlled centrifugal force with the capillary action to enable basic liquid handling steps such as blood separation, liquid recirculation, liquid routing and valving. The integration...
This work introduces a toolkit of structures based on centrifugo-pneumatic actuation that allows for liquid loading/transfer, metering, mixing and sedimentation in a microstructured polymer disc. This pneumatic cascade leverages full integration and automation of a range of bioassays initiated by a single sample reagent loading phase and using the same fluidic pathway for a sequence of sample and...
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