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Background
HLA‐B*15:02 is a known biomarker for carbamazepine (CBZ)‐induced Stevens‐Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) in some ethnic populations. The US FDA recommends B*15:02 screening for Asian and other populations with a high prevalence of B*15:02 prior to treatment with CBZ to prevent drug‐related SJS/TEN.
Materials and Methods
A total of 1607 blood samples were collected...
Human leukocyte antigen HLA‐B*13:01 is identified currently as a marker of individual susceptibility to drug‐induced hypersensitivity reaction, such as dapsone‐induced hypersensitivity reactions (DIHRs) and trichloroethylene‐induced dermatitis. Therefore, screening for the HLA‐B*13:01 allele can assist clinics in identifying patients at risk of developing DIHRs. By combining the allele‐specific primers...
The aim of the study was to investigate and compare the clinical manifestations between HLA‐B27+ and HLA‐B27− ankylosing spondylitis (AS) patients in order to obtain knowledge of the impact of HLA‐B27 status on AS, and to inform clinical treatment. A nationwide epidemiological investigation was performed from November 2008 to October 2010. The demographic data and clinical characteristics, and the...
Hepatitis B virus (HBV) infection is associated with the development of acute and chronic liver diseases including hepatocellular carcinoma (HCC). T‐cell immunoglobulin domain and mucin domain‐containing molecule‐3 (Tim‐3), which negatively regulates T‐cell response and mediates phagocytosis of apoptotic cells, has been implicated in HBV infection and cancers. This study explored the polymorphisms...
Non‐classical human leukocyte antigen (HLA)‐DM plays an important and unique role in the processing and presentation of exogenous antigens. Polymorphisms of certain genes and frequency of alleles in populations may indicate susceptibility to certain diseases. In this study, the analysis of HLA‐DMA and HLA‐DMB gene polymorphisms and haplotypes in the Chinese Han population was conducted to obtain population...
The novel HLA (human leukocyte angiten)‐A*26 allele differs from A*26:01:01 by a single nucleotide substitution at position 292 of exon 2 where a ‘G’ change to ‘C’.
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