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The relevance of innate immune responses to Plasmodium falciparum infection, in particular the central role of natural killer (NK) cell‐derived interferon gamma (IFN‐γ), is becoming increasingly recognised. Recently, it has been shown that IFN‐γ production in response to P. falciparum antigens is in part regulated by killer‐cell immunoglobulin‐like receptor (KIR) genes, and a study from malaria‐exposed...
IgG and IgG3 antibodies to merozoite surface protein‐2 (MSP‐2) of Plasmodium falciparum have been associated with protection from clinical malaria in independent studies. We determined whether this protection was allele‐specific by testing whether children who developed clinical malaria lacked IgG/IgG3 antibodies specific to the dominant msp2 parasite genotypes detected during clinical episodes. We...
Information on the period during which infants lose their maternally derived antibodies to malaria and begin to acquire naturally their own immune responses against parasite antigens is crucial for understanding when malaria vaccines may be best administered. This study investigated the rates of decline and acquisition of serum antibody isotypes IgG1, IgG2, IgG3, IgG4, IgM and IgA to Plasmodium falciparum...
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