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The feasibility of using subharmonic aided pressure estimation (SHAPE) to noninvasively estimate interstitial fluid pressure (IFP) was studied. In vitro, radiofrequency signals, from 0.2ml/l of Definity (Lantheus Medical Imaging, N Billerica, MA) were acquired within a water-tank with a Sonix RP ultrasound scanner (Analogic Ultrasound, Richmond, BC, Canada; f T/R =6.7/3.35MHz and f T/R...
The purpose of this study was to compare 4 contrast-enhanced ultrasound (US) techniques for measuring tumor neovascularity to 4 markers of angiogenesis in 2 xenograft rat models. Glioma (C6; 75 rats) or breast cancer (NMU; 72 rats) cells were implanted in 147 rats. The US contrast agent Optison (GE Healthcare, Princeton, NJ) was injected in a tail vein (dose: 0.4 ml/kg). Power Doppler imaging (PDI),...
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