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Human leukocyte antigen (HLA)‐B27 is closely associated with ankylosing spondylitis (AS). However, the exact correlation between HLA‐B27 subtypes and AS manifestations remains unknown. This study aimed to investigate the correlation between HLA‐B27 polymorphism and the clinical features of AS. This study included 846 patients with AS and 959 healthy controls. Direct sequencing was used to identify...
The aim of the study was to investigate and compare the clinical manifestations between HLA‐B27+ and HLA‐B27− ankylosing spondylitis (AS) patients in order to obtain knowledge of the impact of HLA‐B27 status on AS, and to inform clinical treatment. A nationwide epidemiological investigation was performed from November 2008 to October 2010. The demographic data and clinical characteristics, and the...
The human leukocyte antigen HLA‐A*31:22 allele shows a single nucleotide change at position 245 (A > C) of exon 2 from the closest matching allele HLA‐A*31:01:02.
Abstract
Distribution of B27 subtypes in juvenile and adult‐onset ankylosing spondylitis (JAS and AAS) in Southern China was studied. A total of 505 patients belonged to Han population were included (145 JAS and 360 AAS patients), and 1368 healthy individuals were included as controls. Human leukocyte antigen (HLA)‐B27 typing was performed by Luminex liquid array combining polymerase chain reaction‐sequence...
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