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In addition to its well‐characterized role in the central nervous system, human glutamate carboxypeptidase II (GCPII; Uniprot ID Q04609) acts as a folate hydrolase in the small intestine, participating in the absorption of dietary polyglutamylated folates (folyl‐n‐γ‐l‐glutamic acid), which are the provitamin form of folic acid (also known as vitamin B9). Despite the role of GCPII as a folate hydrolase,...
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