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Coating nanoparticles with poly(ethylene glycol) (PEG) is widely used to achieve long‐circulating properties after infusion. While PEG reduces binding of opsonins to the particle surface, immunogenic anti‐PEG side‐effects show that PEGylated nanoparticles are not truly “stealth” to surface active proteins. A major obstacle for understanding the complex interplay between opsonins and nanoparticles...
Ficolin-3 (Hakata antigen or H-ficolin) is a soluble pattern recognition molecule in the lectin complement pathway. We speculated whether common genetic variations in the FCN3 gene contribute to deficiency of Ficolin-3.The FCN3 gene was sequenced in 237 healthy Danish Caucasians. The relevance of polymorphisms was assessed with antibodies against Ficolin-3 in a novel ELISA system and by production...
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