Search results for: S. J. Stanworth

Items from 1 to 20 out of 28 results

article

Harnessing the potential of data‐driven strategies to optimise transfusion practice

H. G. Evans, M. F. Murphy, R. Foy, P. Dhiman, more

British Journal of Haematology > 204 > 1 > 74 - 85

No one doubts the significant variation in the practice of transfusion medicine. Common examples are the variability in transfusion thresholds and the use of tranexamic acid for surgery with likely high blood loss despite evidence‐based standards. There is a long history of applying different strategies to address this variation, including education, clinical guidelines, audit and feedback, but the...

article

Major haemorrhage: past, present and future

A. Shah, V. Kerner, S. J. Stanworth, S. Agarwal

Anaesthesia > 78 > 1 > 93 - 104

Major haemorrhage is a leading cause of morbidity and mortality worldwide. Successful treatment requires early recognition, planned responses, readily available resources (such as blood products) and rapid access to surgery or interventional radiology. Major haemorrhage is often accompanied by volume loss, haemodilution, acidaemia, hypothermia and coagulopathy (factor consumption and fibrinolysis)...

article

Prevalence, management and outcomes associated with anaemia in ICU survivors: a retrospective study

A. Shah, S. J. Stanworth, A. Lee, L. Johnston, more

Anaesthesia > 76 > 10 > 1421 - 1423

article

The effect of iron deficiency and anaemia on women’s health

C. S. Benson, A. Shah, S. J. Stanworth, C. J. Frise, more

Anaesthesia > 76 > S4 > 84 - 95

Iron deficiency and anaemia are global health problems and major causes of morbidity in women. Current definitions of anaemia in women are historic and have been challenged by recent data from observational studies. Menstrual loss, abnormal uterine bleeding and pregnancy put women at risk of developing iron deficiency which can result in severe fatigue, reduced exercise capacity and poor work performance...

article

The association of pre‐operative anaemia with morbidity and mortality after emergency laparotomy

H. Boyd‐Carson, A. Shah, A. Sugavanam, J. Reid, more

Anaesthesia > 75 > 7 > 904 - 912

Pre‐operative anaemia is associated with poor outcomes after elective surgery but its relationship with outcomes after emergency surgery is unclear. We analysed National Emergency Laparotomy Audit data from 1 December 2013 to 30 November 2017, excluding laparotomy for haemorrhage. Anaemia was classified as ‘mild’ 129–110 g.l−1; ‘moderate’ 109–80 g.l−1; or ‘severe’ ≤ 79 g.l−1. The primary outcome was...

article

Restrictive blood transfusion – is less really more?

A. Shah, S. J. Stanworth, A. B. Docherty

Anaesthesia > 75 > 4 > 433 - 437

article

Approaches to understanding and interpreting the risks of red blood cell transfusion in neonates

A. K. Keir, H. New, N. Robitaille, G. L. Crighton, more

Transfusion Medicine > 29 > 4 > 231 - 238

In this review, we explore how to assess potential harm related to neonatal transfusion practice. We consider different sources of information, including passive or active surveillance systems such as registries, observational studies, randomised trials and systematic reviews. Future research directions are discussed.

article

Use of granulocyte transfusions among haematology units in England and North Wales

S. Morton, A. Mijovic, D. I. Marks, J. Griffin, more

Transfusion Medicine > 28 > 3 > 243 - 248

Objectives To establish the current use of granulocyte transfusions in haematology patients and explore interest in further research. Background Granulocytes may be used for the treatment of severe infection in neutropenic patients or for primary or secondary prophylaxis. Clinical utility of granulocyte transfusions is unclear, and recent studies have demonstrated equivocal outcomes. Pooled granulocytes...

article

Effect of treatment delay on the effectiveness and safety of antifibrinolytics in acute severe hemorrhage

M. J. R. Desborough, C. A. T. Hildyard, S. J. Stanworth

Journal of Thrombosis and Haemostasis > 16 > 6 > 1025 - 1027

article

Patient blood management, what does this actually mean for neonates and infants?

G. L. Crighton, H. V. New, H. G. Liley, S. J. Stanworth

Transfusion Medicine > 28 > 2 > 117 - 131

Patient blood management (PBM) refers to an evidence‐based package of care that aims to improve patient outcomes by optimal use of transfusion therapy, including managing anaemia, preventing blood loss and improving anaemia tolerance in surgical and other patients who may need transfusion. In adults, PBM programmes are well established, yet the definition and implementation of PBM in neonates and...

article

A multicentred study to validate a consensus bleeding assessment tool developed by the biomedical excellence for safer transfusion collaborative for use in patients with haematological malignancy

C. Dyer, C. R. Alquist, M. Cole‐Sinclair, E. Curnow, more

Vox Sanguinis > 113 > 3 > 251 - 259

Background There continues to be uncertainty about the optimal approach to documenting bleeding data in platelet transfusion trials, with a desire to apply a common assessment tool across all trials. With this in mind, a consensus bleeding assessment tool (BAT) has been developed by the Biomedical Excellence for Safer Transfusion (BEST) collaborative, based on review of data collection forms used...

article

Thromboelastography may predict risk of grade 2 bleeding in thrombocytopenic patients

E. N. Opheim, T. O. Apelseth, S. J. Stanworth, G. E. Eide, more

Vox Sanguinis > 112 > 6 > 578 - 585

Background and objectives Platelet count is used as a prophylactic platelet transfusion trigger, although evidence suggests that it is a poor predictor of bleeding. Thus, alternative tests are required. The primary objective of this study was to compare thromboelastography (TEG) parameters on days with and without bleeding symptoms. The secondary objectives were to investigate the relationship between...

article

Diagnostic criteria for pre‐operative anaemia–time to end sex discrimination

A. Butcher, T. Richards, S. J. Stanworth, A. A. Klein

Anaesthesia > 72 > 7 > 811 - 814

article

Factors influencing plasma transfusion practices in paediatric intensive care units around the world

O. Karam, P. Demaret, A. Duhamel, A. Shefler, more

Vox Sanguinis > 112 > 2 > 140 - 149

Background and Objectives Plasma transfusions are a frequent treatment worldwide, but many studies have reported a wide variation in the indications to transfuse. Recently, an international paediatric study also showed wide variation in frequency in the use of plasma transfusions: 25% of the centres transfused plasma to >5% of their patients, whereas another 25% transfused plasma to <1% of...

article

Desmopressin for treatment of platelet dysfunction and reversal of antiplatelet agents: a systematic review and meta‐analysis of randomized controlled trials

M. J. R. Desborough, K. A. Oakland, G. Landoni, M. Crivellari, more

Journal of Thrombosis and Haemostasis > 15 > 2 > 263 - 272

Summary Background Platelet dysfunction, including that caused by antiplatelet agents, increases the risk of perioperative bleeding. The optimal management of patients with platelet dysfunction undergoing surgery is unclear. Objectives To assess whether desmopressin reduces perioperative allogeneic red cell transfusion and bleeding in patients with platelet dysfunction. Patients/Methods...

article

ESICM LIVES 2016: part one

L. Bos, L. Schouten, L. van Vught, M. Wiewel, more

Intensive Care Medicine Experimental > 2016 > 4 > 1 > 1-203

article

An update on indications for platelet transfusion

E. M. Wood, G. L. Crighton, L. J. Estcourt, Z. K. McQuilten, more

ISBT Science Series > 11 > S2 > 170 - 176

Platelets are very commonly prescribed blood components, and in many settings, their use is increasing. They may be used either prophylactically (to attempt to prevent bleeding) or therapeutically (to treat bleeding when it occurs). This review provides a summary of the major clinical settings in which platelet transfusions are currently used. Most platelet transfusions are provided prophylactically...

article

Spotlight on platelets: summary of BBTS combined special interest group autumn meeting, November 2015

M. F. Murphy, R. Gill, R. Moss, M. Raghavan, more

Transfusion Medicine > 26 > 1 > 8 - 14

This conference first addressed aspects of component quality, highlighting the role of pathogen inactivation, the role of PAS or plasma in prolonging platelet viability and acceptable storage deviations. A series of talks on the medical use of platelets covered the role of platelet transfusion in preventing intracranial haemorrhage, platelet prophylaxis in haematological patients and the new trial...

article

Mortality from trauma haemorrhage and opportunities for improvement in transfusion practice

S. J. Stanworth, R. Davenport, N. Curry, F. Seeney, more

British Journal of Surgery > 103 > 4 > 357 - 365

BackgroundThe aim of this study was to describe the prevalence, patterns of blood use and outcomes of major haemorrhage in trauma. MethodsThis was a prospective observational study from 22 hospitals in the UK, including both major trauma centres and smaller trauma units. Eligible patients received at least 4 units of packed red blood cells (PRBCs) in the first 24 h of admission with activation of...

article

Do all patients with haematological malignancies need prophylactic platelets? No

S. J. Stanworth, L. Estcourt, C. Hudson, E. Wood, more

ISBT Science Series > 11 > S1 > 178 - 181

Nearly, all patients, whether receiving treatment with autologous hematopoietic stem cell transplantation (autoHSCT), intensive chemotherapy or allogeneic HSCT (alloHSCT), will receive one or more transfusions of platelets, most as prophylaxis. Optimal use of prophylactic platelet transfusions for prevention of haemorrhage in all patients with treatment‐induced myelosuppression remains controversial...

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INFONA - science communication portal

Search results for: S. J. Stanworth

Harnessing the potential of data‐driven strategies to optimise transfusion practice

Major haemorrhage: past, present and future

Prevalence, management and outcomes associated with anaemia in ICU survivors: a retrospective study

The effect of iron deficiency and anaemia on women’s health

The association of pre‐operative anaemia with morbidity and mortality after emergency laparotomy

Restrictive blood transfusion – is less really more?

Approaches to understanding and interpreting the risks of red blood cell transfusion in neonates

Use of granulocyte transfusions among haematology units in England and North Wales

Effect of treatment delay on the effectiveness and safety of antifibrinolytics in acute severe hemorrhage

Patient blood management, what does this actually mean for neonates and infants?

A multicentred study to validate a consensus bleeding assessment tool developed by the biomedical excellence for safer transfusion collaborative for use in patients with haematological malignancy

Thromboelastography may predict risk of grade 2 bleeding in thrombocytopenic patients

Diagnostic criteria for pre‐operative anaemia–time to end sex discrimination

Factors influencing plasma transfusion practices in paediatric intensive care units around the world

Desmopressin for treatment of platelet dysfunction and reversal of antiplatelet agents: a systematic review and meta‐analysis of randomized controlled trials

ESICM LIVES 2016: part one

An update on indications for platelet transfusion

Spotlight on platelets: summary of BBTS combined special interest group autumn meeting, November 2015

Mortality from trauma haemorrhage and opportunities for improvement in transfusion practice

Do all patients with haematological malignancies need prophylactic platelets? No

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