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Objective
Cairn terriers with ocular melanosis (OM) accumulate large, heavily pigmented melanocytes in the anterior uvea. Darkly pigmented plaques develop within the sclera, leading us to hypothesize that OM uveal melanocytes may have an abnormal migratory capacity.
Animals studied
Globes from OM‐affected Cairn terriers and unaffected control eyes enucleated for reasons unrelated to this study...
ObjectivesTo establish a method for isolation and culture of canine uveal melanocytes.
Animals studiedUveal explants from five mixed‐breed dogs.
ProceduresDonor globes were dissected, and the anterior uvea removed. The uveal explants were placed in trypsin solution for enzymatic digestion. Extracted cells were cultured in modified F12 media. Immunocytochemistry was performed to confirm the identity...
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