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Retromer, a peripheral membrane protein complex, plays an instrumental role in host of cellular processes by its ability to recycle receptors from endosomes to the trans‐Golgi network. It consists of two distinct sub‐complexes, a membrane recognizing, sorting nexins (SNX) complex and a cargo recognition, vacuolar protein sorting (Vps) complex. Small GTPase, Rab7 is known to recruit retromer on endosomal...
We describe a straightforward strategy for the synthesis of strongly fluorescent pyridoindoles by Pd‐catalyzed oxidative annulations of internal alkynes with C‐3 functionalized indoles through CH/NH bond activation in a one‐pot tandem process. Mechanistic investigations reveal the preferential activation of NH indole followed by CH activation during the cyclization process. Photophysical properties...
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