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Living organisms possess mechanisms to safeguard genome integrity. To avoid spreading mutations, DNA lesions are detected and cell division is temporarily arrested to allow repair mechanisms. Afterward, cells either resume division or respond to unsuccessful repair by undergoing programmed cell death (PCD). How the success rate of DNA repair connects to later cell fate decisions remains incompletely...
Precise coordination of cell differentiation and division within a tissue context is critical for plant development. In this issue of Developmental Cell, Han et al. (2018) report a transcriptional switch that ensures proper patterning, the final cell division, and terminal differentiation of stomata.
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