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Abstract
Dopamine neurons in the ventral tegmental area (VTA) are strongly innervated by GABAergic neurons in the ‘tail of the VTA’ (tVTA), also known as the rostralmedial tegmental nucleus (RMTg). Disinhibition of dopamine neurons through firing of the GABAergic neurons projecting from the lateral hypothalamus (LH) leads to reward seeking and consumption through dopamine release in the nucleus accumbens...
Key points
Fasting can increase motivation for food and can energize reward‐seeking.
Ventral tegmental area (VTA) dopamine neurons respond to motivationally relevant information and fasting can influence mesolimbic dopamine concentration.
An acute overnight fast differentially alters food approach behaviours and excitatory synaptic transmission onto VTA dopamine neurons of male or female mice.
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