Search results for: Abhay Dhand

Items from 1 to 20 out of 20 results

article

Severe COVID‐19 in solid organ transplant recipients in the post‐vaccination era: Persistence in the burden of disease and in disparities of care

Abhay Dhand, Kenji Okumura, Seigo Nishida

Transplant Infectious Disease > 26 > 1 > n/a - n/a

article

Utilization of hepatitis C virus infected donors in heart transplant recipients with elevated MELD‐XI score

Rahim Hirani, Kenji Okumura, Ameesh Isath, Vasiliki Gregory, more

Clinical Transplantation > 37 > 12 > n/a - n/a

Background The advent of direct‐acting antivirals has helped to increase the safe utilization of organs from hepatitis C virus positive (HCV+) donors. However, the outcomes of heart transplantation (HT) using an HCV+ donor are unclear in recipients with underlying liver disease represented by an elevated model for end‐stage liver disease excluding international normalized ratio (MELD‐XI). Methods...

article

Groin wound management after decannulation of veno‐arterial extracorporeal membrane oxygenation in heart transplantation: Role of sartorius muscle flap

Ameesh Isath, Vasiliki Gregory, Suguru Ohira, Avi Levine, more

Clinical Transplantation > 37 > 12 > n/a - n/a

Background The management of complex groin wounds following VA‐ECMO after heart transplant (HT) is uncertain due to limited experience. Sartorius muscle flaps (SMF) have been used in vascular surgery for groin wound complications. However, their use in HT recipients with perioperative VA‐ECMO is unclear. This study aims to describe characteristics and outcomes of HT patients with groin complications...

article

Successful bilateral lung transplantation from a recent SARS‐CoV‐2 PCR positive donor

Soma S. S. K Jyothula, Jayeshkumar Patel, Abhay Dhand

Transplant Infectious Disease > 25 > 3 > n/a - n/a

article

Utilization and discard of organs from donors with COVID‐19 in the United States

Kenji Okumura, Seigo Nishida, Abhay Dhand

Clinical Transplantation > 37 > 3 > n/a - n/a

article

Cannulation‐related adverse events of peripheral veno‐arterial extracorporeal membrane oxygenation support in heart transplantation: Axillary versus femoral artery cannulation

Suguru Ohira, Abhay Dhand, Rahim Hirani, Sabrina Martinez, more

Clinical Transplantation > 37 > 3 > n/a - n/a

Background In heart transplantation (HT), peripheral veno‐arterial extracorporeal membranous oxygenation (VA‐ECMO) is utilized preoperatively as a direct bridge to HT or postoperatively for primary graft dysfunction (PGD). Little is known about wound complications of an arterial VA‐ECMO cannulation site which can be fatal. Methods From 2009 to 2021, outcomes of 80 HT recipients who were supported...

article

Solid organ transplantation from COVID positive donors in the United States: Analysis of United Network for Organ Sharing database

Abhay Dhand, Kenji Okumura, Christopher Nabors, Seigo Nishida

Transplant Infectious Disease > 25 > 1 > n/a - n/a

Background Significant uncertainties remain regarding the utilization of organs for solid organ transplantation (SOT) from donors with coronavirus disease 2019 (COVID‐19). The aim of this study was to assess the trends in utilization of organs from donors with COVID‐19 and their short‐term outcomes. Methods Deceased donors between March 2020 and December 2021 with a positive COVID nucleic acid...

article

Promising role of two‐dimensional shear wave elastography in the prediction of long‐term morbidity and mortality after liver transplantation

Kenji Okumura, Abhay Dhand, Roxana Bodin, Seigo Nishida

Liver Transplantation > 28 > 11 > 1806 - 1806

article

Does utilization of heart machine perfusion for donation after cardiac death transplantation affect outcomes of other abdominal transplanted organs?

Kenji Okumura, Ryosuke Misawa, Suguru Ohira, Abhay Dhand, more

Clinical Transplantation > 36 > 9 > n/a - n/a

Introduction Machine perfusion of heart for donation after circulatory death (DCD) is being increasingly utilized. Current protocols for utilizing heart DCD's machine perfusion might prolong donor warm ischemic time for nonheart organs. The aim of this study was to analyze the effects of utilizing heart machine perfusion on liver and kidney transplants from the same donor. Methods We analyzed data...

article

Re: The impact of machine perfusion of the heart on warm ischemia time and organ yield in donation after circulatory death

Kenji Okumura, Ryosuke Misawa, Suguru Ohira, Abhay Dhand, more

American Journal of Transplantation > 22 > 8 > 2122 - 2123

article

Acute kidney injury following liver transplantation: Pitfalls in the interpretation of risk factors

Kenji Okumura, Abhay Dhand, Ryosuke Misawa, Seigo Nishida

Liver Transplantation > 28 > 8 > 1397 - 1398

article

Successful transplantation of organs from a deceased donor with early SARS‐CoV‐2 infection

Abhay Dhand, Alan Gass, Seigo Nishida, Masashi Kai, more

American Journal of Transplantation > 21 > 11 > 3804 - 3805

article

Successful liver transplantation in a patient recovered from COVID‐19

Abhay Dhand, Roxana Bodin, David C. Wolf, Aaron Schluger, more

Transplant Infectious Disease > 23 > 2 > n/a - n/a

Transplantation in potential candidates who have recently recovered from COVID‐19 is a challenge with uncertainties regarding the diagnosis, multi‐organ systemic involvement, prolonged viral shedding in immunocompromised patients, and optimal immunosuppression. A 42 year male with alcoholic hepatitis underwent a successful deceased donor liver transplantation 71 days after the initial diagnosis of...

article

Bamlanivimab for treatment of COVID‐19 in solid organ transplant recipients: Early single‐center experience

Abhay Dhand, Stephen A. Lobo, Kevin Wolfe, Nicholas Feola, more

Clinical Transplantation > 35 > 4 > n/a - n/a

article

Challenges of Shared Decision Making in Older Patients with COVID‐19

Abhay Dhand, Leanne Forman, Rathnamitreyee Vegunta, Wilbert S. Aronow, more

Journal of the American Geriatrics Society > 69 > 3 > 605 - 606

article

Anaplasma phagocytophilum presenting with orchitis in a renal transplant recipient

Akshay Khatri, Amanda Lloji, Richard Doobay, Guiqing Wang, more

Transplant Infectious Disease > 21 > 4 > n/a - n/a

Human granulocytic anaplasmosis (HGA), caused by Anaplasma phagocytophilum, is an emerging tick‐borne disease. It is spread by the black‐legged deer tick Ixodes scapularis that serves as the vector for six human pathogens. HGA is still rarely reported in solid organ transplant recipients. In solid organ transplant recipients, orchitis has been reported secondary to chickenpox, tuberculosis and infections...

chapter

Mechanism of Resistance in Metronidazole

Abhay Dhand, David R. Snydman

Infectious Disease > Antimicrobial Drug Resistance > Bacterial Drug Resistance – Mechanisms > 223-227

Metronidazole [1-(2 hydroxyethyl)-2-methyl-5-nitroimidazole] was introduced in the 1960s. Since then it has been drug of choice for human infections caused by various anaerobic and microaerophilic bacteria (Bacteroides, Clostridia, Helicobacter) and parasites (Trichomonas, Giardia, Entamoeba). Other Gram-positive anaerobes (e.g., lactobacilli, propionobacterium acnes, majority of the periodontal pathogens,...

article

Antimicrobial Salvage Therapy for Persistent Staphylococcal Bacteremia Using Daptomycin Plus Ceftaroline

George Sakoulas, Pamela A. Moise, Anthony M. Casapao, Poochit Nonejuie, more

Clinical Therapeutics > 2014 > 36 > 10 > 1317-1333

Guidelines recommend daptomycin combination therapy as an option for methicillin-resistant Staphylococcus aureus (MRSA) bacteremia after vancomycin failure. Recent data suggest that combining daptomycin with a β-lactam may have unique benefits; however, there are very limited clinical data regarding the use of ceftaroline with daptomycin.All 26 cases from the 10 medical centers in which ceftaroline...

article

Daptomycin in Combination With Other Antibiotics for the Treatment of Complicated Methicillin-Resistant Staphylococcus aureus Bacteremia

Abhay Dhand, George Sakoulas

Clinical Therapeutics > 2014 > 36 > 10 > 1303-1316

Methicillin-resistant Staphylococcus aureus (MRSA) has emerged as one of the most important nosocomial pathogens. Resistance to antibiotic therapy has been known to emerge especially in clinically complex scenarios, resulting in challenges in determining optimal treatment of serious MRSA. Daptomycin, in combination with other antibiotics, has been successfully used in the treatment of these infections,...

article

Nafcillin enhances innate immune-mediated killing of methicillin-resistant Staphylococcus aureus

George Sakoulas, Cheryl Y. Okumura, Wdee Thienphrapa, Joshua Olson, more

Journal of Molecular Medicine > 2014 > 92 > 2 > 139-149

Based on in vitro synergy studies, the addition of nafcillin to daptomycin was used to treat refractory methicillin-resistant Staphylococcus aureus (MRSA) bacteremia. Daptomycin is a de facto cationic antimicrobial peptide in vivo, with antistaphylococcal mechanisms reminiscent of innate host defense peptides (HDPs). In this study, the effects of nafcillin on HDP activity against MRSA were examined...

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