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Adeno‐associated virus (AAV)‐based gene therapy holds promise as a fundamental treatment for genetic disorders. For clinical applications, it is necessary to control AAV release timing to avoid an immune response to AAV. Here we propose an ultrasound (US)‐triggered on‐demand AAV release system using alginate hydrogel microbeads (AHMs) with a release enhancer. By using a centrifuge‐based microdroplet...
Alginate Hydrogel Microbeads
In article number 2204139, Hiroaki Onoe and co‐workers present near‐infrared (NIR) triggered on‐demand adeno‐associated virus (AAV) release from alginate microbeads with heat transducer for gene therapy. The heat transducer encapsulated in microbeads generate heat under NIR‐irradiation. Subsequently, AAV release from the microbeads could be controlled on‐demand by the...
Gene therapy using adeno‐associated virus (AAV) has potential as a radical treatment modality for genetic diseases such as sensorineural deafness. To establish clinical applications, it is necessary to avoid immune response to AAV by controlled release system of AAV. Here, a near‐infrared (NIR)‐triggered on‐demand AAV release system using alginate hydrogel microbeads with a heat transducer is proposed...
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