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BackgroundFarm exposure has been shown to protect from childhood asthma and allergic diseases, but underlying immunological mechanisms are not clear yet.
ObjectiveTo explore whether farming lifestyle determines cytokine profile of peripheral blood mononuclear cells (PBMCs) of 4.5‐year‐old children (n = 88) from the Finnish PASTURE birth cohort study.
MethodsWe analysed regulatory (IL‐10, IL‐2),...
Farm environment has been shown to protect from childhood asthma. Underlying immunological mechanisms are not clear yet, including the role of dendritic cells (DCs). The aim was to explore whether asthma and farm exposures are associated with the proportions and functional properties of DCs from 4.5‐year‐old children in a subgroup of the Finnish PASTURE birth cohort study. Myeloid DCs (mDCs), plasmacytoid...
BackgroundEarly life farm exposures have been shown to decrease the risk of allergic diseases. Dendritic cells (DCs) may mediate asthma‐protective effect of farm exposures as they play an important role in the development of immunity and tolerance. Our aim was to investigate whether the numbers and phenotypes of circulating DCs at age 6 are associated with farming, asthma, and atopy in a selected...
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