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A prospective identification of the estimated 20–50% of pediatric LTX recipients developing operational tolerance would be of great clinical advantage. So far markers of immune tolerance – T‐cell subpopulations or gene expression profiles – have been investigated only retrospectively in successfully weaned patients. Fifty children aged 8–265 months (median 89) were investigated 1–180 months (median...
γδ T cells play an important role in anti‐infective immunity. The major subset of human γδ T cells selectively recognizes phosphorylated bacterial metabolites of the isoprenoid biosynthesis pathway, so‐called phosphoantigens. The activation of γδ T cells is modulated by functionally expressed innate immune receptors, notably Toll‐like receptor 2 and 3. It was also reported that in vitro expanded γδ...
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