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Interaction between the immune system and cancer allows for the use of biological response modifiers, e.g. OK‐432, in cancer therapy. OK‐432, penicillin‐killed Streptococcus pyogenes, is used in treating carcinomas, but also lymphangiomas. We have studied the role of monocytes (MOs) in the immune response to OK‐432 by examining IL‐6 and tumour necrosis factor (TNF)‐α secretion after in vitro MO stimulation...
Biopsies from carcinoma tissue and benign control mucosa from head and neck squamous cell carcinoma patients were used to establish fragment (F)-spheroids in vitro. We have previously shown that autologous monocytes co-cultured with F-spheroids in vitro secrete interleukin (IL)-6 upon 24h in co-culture. Presently, the aim was to study the mechanisms of this monocyte secretion. Paraformaldehyde (0...
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