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For semi‐competing risks data involving a non‐terminal event and a terminal event we derive the asymptotic distributions of the event‐specific win ratios under proportional hazards (PH) assumptions for the relevant cause‐specific hazard functions of the non‐terminal and terminal event, respectively. The win ratios converge to the respective hazard ratios under the PH assumptions and therefore are...
In an infectious disease cohort study, individuals who have been infected with a pathogen are often recruited for follow up. The period between infection and the onset of symptomatic disease, referred to as the incubation period, is of interest because of its importance on disease surveillance and control. However, the incubation period is often difficult to ascertain due to the uncertainty associated...
Background
Poor outcomes for patients with ovarian cancer relate to dormant, drug‐resistant cancer cells that survive after primary surgery and chemotherapy. Ovarian cancer (OvCa) cells persist in poorly vascularized scars on the peritoneal surface and depend on autophagy to survive nutrient deprivation. The authors have sought drugs that target autophagic cancer cells selectively to eliminate residual...
We propose a three‐state frailty Markov model coupled with likelihood‐based inference to analyse tooth level life course data in caries research. This analysis is challenging because of intraoral clustering, interval censoring, multiplicity of caries states and computational complexities. We also develop a Bayesian approach to predict future caries transition probabilities given observed life history...
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