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BACKGROUND
Ionotropic γ‐aminobutyric acid (GABA) receptor (GABAR) in an insect is the major inhibitory receptor and is one of the most important targets for insecticides. Due to the high spatiotemporal resolution of GABAR, the photopharmacological ligands acting on it in vertebrates but not insect have been developed.
RESULTS
In this study, two types of photochromic ligands (PCLs) including DTFIPs...
1,8-Naphthyridines (NAP) are biological important scaffolds in bioactive molecules design. By hybrid of NAP with neonicotinoid core structure, nine novel NAP derivatives were synthesized and subjected to insecticidal activities evaluation. Some of the compounds showed excellent insecticidal activity against cowpea aphids (Aphis craccivora) with LC50 values ranging from 0.011mmol/L to 0.067mmol/L....
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