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cAMP response element binding Protein 3 (CREB3) is an endoplasmic reticulum (ER) membrane‐bound transcription factor, which belongs to the basic leucine zipper (bZIP) superfamily of eukaryotic transcription factors. CREB3 plays a role in the ER‐stress induced unfolded protein response (UPR) and is a multifunctional cellular factor implicated in a number of biological processes including cell proliferation...
The T cell immune synapse is important for communication between B cells and T cells. The ILT2 receptor is expressed on T cells and binds MHC I. ILT2 also binds the highly glycosylated human cytomegalovirus MHC I-homologue UL18 at 1000 times greater affinity than native MHC I ligand. The higher affinity viral ligand results in repatterning at the immune synapse and can induce differential signalling,...
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