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DOI: 10.1002/pmic.201700113
The cover art represents the experimental workflow to analyse the biomolecular composition of purified plasma membranes and lysosomes. The methodology is based on the use of superparamagnetic iron oxide nanoparticles (SPIONs) with different functionalized groups. Aminolipid‐coated SPIONs are targeted to the cell surface while DMSA‐coated SPIONs are taken up by cells and...
A eukaryotic cell encompasses many membrane‐enclosed organelles, each of these holding several types of biomolecules that exhibit tremendous diversity in terms of their localization and expression. Despite the development of increasingly sensitive analytical tools, the enormous biomolecular complexity that exists within a cell cannot yet be fully resolved as low abundant molecules often remain unrecognized...
γ-Secretases are a family of intramembrane-cleaving proteases involved in various signaling pathways and diseases, including Alzheimer’s disease (AD). Cells co-express differing γ-secretase complexes, including two homologous presenilins (PSENs). We examined the significance of this heterogeneity and identified a unique motif in PSEN2 that directs this γ-secretase to late endosomes/lysosomes via a...
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