The Infona portal uses cookies, i.e. strings of text saved by a browser on the user's device. The portal can access those files and use them to remember the user's data, such as their chosen settings (screen view, interface language, etc.), or their login data. By using the Infona portal the user accepts automatic saving and using this information for portal operation purposes. More information on the subject can be found in the Privacy Policy and Terms of Service. By closing this window the user confirms that they have read the information on cookie usage, and they accept the privacy policy and the way cookies are used by the portal. You can change the cookie settings in your browser.
Objective
We tested the hypothesis that FMR1 expansions would result in global gene dysregulation as early as the second trimester of human fetal development.
Method
Using cell‐free fetal RNA obtained from amniotic fluid supernatant and expression microarrays, we compared RNA levels in samples from fetuses with premutation or full mutation allele expansions with control samples.
Results
We found...
ObjectiveThe aim of this study was to compare the complexity of the amniotic fluid supernatant cell‐free fetal transcriptome as described by RNA Sequencing (RNA‐Seq) and gene expression microarrays.
MethodsCell‐free fetal RNA from the amniotic fluid supernatant of five euploid mid‐trimester samples was divided and prepared in tandem for analysis by either the Affymetrix HG‐U133 Plus 2.0 Gene Chip...