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Purpose
We report the results of the French multicentric phase II study MIITOP (NCT00960739), which evaluated tandem infusions of 131I‐metaiodobenzylguanidine (mIBG) and topotecan in children with relapsed/refractory metastatic neuroblastoma (NBL).
Methods
Patients received 131I‐mIBG on day 1, with intravenous topotecan daily on days 1–5. A second activity of 131I‐mIBG was given on day 21 to deliver...
Antithymocyte globulin is a major drug in transplantation. rATG has been successfully used to prevent graft‐versus‐host disease in allogeneic HSCT. However, its first infusion is associated with reactions ranging from simple fevers to distributive shocks and may interfere with the transplant conditioning. To evaluate the impact of rATG infusion rate on clinical tolerability, we conducted a retrospective...
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