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Survival following childhood neuroblastoma is improving with low rates of secondary myeloid neoplasms. We describe a 13‐month‐old male with intermediate risk neuroblastoma who developed an isolated scalp therapy‐related myeloid sarcoma (t‐MS). Developmental delays and two distinct malignancies prompted constitutional evaluation. Chromosomal microarray identified a 7.3 Mb deletion of 9q22.32 to 9q31...