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Methionine aminopeptidase 1 (MetAP1) is a target for drug discovery against many adversaries and a potential antileishmanial target for its role in N‐terminal methionine processing. As an effort towards new inhibitor discovery against methionine aminopeptidase 1 from Leishmania donovani (LdMetAP1), we have synthesized a series of quinoline‐based hybrids, that is (Z)‐5‐((Z)‐benzylidine)‐2‐(quinolin‐3‐ylimino)thiazolidin‐4‐ones...
BackgroundTo determine the prevalence of and risk factors for primary hypothyroidism following treatment with a radiolabeled monoclonal antibody (131I‐3F8) in children with neuroblastoma.
ProcedureIn the current study, we assessed thyroid function in 51 neuroblastoma patients who survived for ≥3 months after treatment with 131I‐3F8 (a murine IgG3 monoclonal antibody that reacts with the ganglioside...
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