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Oral Diseases (2011) 17, 355–361
Anoikis – apoptotic cell death triggered by loss of extracellular matrix (ECM) contacts – is dysregulated in many chronic debilitating and fatal diseases. Mechanisms rendering tumor cells resistant to anoikis, although not completely understood, possess significant therapeutic promise. In death receptor‐mediated anoikis mechanisms, focal adhesion kinase (FAK) and receptor‐interacting...