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Background
Pepsin in saliva is a proposed biomarker for oropharyngeal reflux. Pepsin may be prevalent in saliva from subjects with gastro‐esophageal reflux and may correlate with proximal reflux by intraluminal impedance/pH monitoring (MII/pH).
Methods
Patients (3 days to 17.6 years, n=90) undergoing 24‐hour MII/pH monitoring and asymptomatic controls (2 months to 13.7 years, n=43) were included...