The Infona portal uses cookies, i.e. strings of text saved by a browser on the user's device. The portal can access those files and use them to remember the user's data, such as their chosen settings (screen view, interface language, etc.), or their login data. By using the Infona portal the user accepts automatic saving and using this information for portal operation purposes. More information on the subject can be found in the Privacy Policy and Terms of Service. By closing this window the user confirms that they have read the information on cookie usage, and they accept the privacy policy and the way cookies are used by the portal. You can change the cookie settings in your browser.
CD4 + lymphocytes exhibit variable permissiveness to the replication of HIV-1. A cohort of sexually-exposed-yet-uninfected individuals were previously shown to have CD4 + lymphocytes refractory for M-tropic viral replication. In particular, two individuals from this population whose CD4 + lymphocytes exhibited complete resistance to M-tropic viral replication were later shown...
It is now well established that an array of CC and CXC chemokine receptors, in association with the CD4 molecule, can interact with the HIV-1 gp120 protein to facilitate viral fusion. A 32bp deletion in the CC chemokine receptor CCR5, the major M-tropic viral co-receptor, provides considerable protection against HIV-1 transmission and has been associated with a delay in disease progression. The effects...
We examined the human immunodeficiency virus type 1 infectability of CD4+lymphocytes isolated from CCR5 wild-type individuals, individuals heterozygous for the Δ32 allele of CCR5, and HIV-1-exposed but uninfected (EU) individuals who had CD4+lymphocytes refractory to M-tropic viral replication. None of the EU individuals were found to be heterozygous for the Δ32 allele. The CD4+lymphocytes isolated...
Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.