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The intracellular pathogen Legionella pneumophila translocates more than 300 effector proteins into host cells during infection. The PmrAB two‐component system (TCS) has been shown to activate the expression of a large pool of these effector‐encoding genes (EEGs) and the LetAS TCS, as part of the LetAS‐RsmYZ‐CsrA cascade, has been shown to repress the expression of another pool of EEGs. We identified...
Legionella pneumophila utilizes the Icm/Dot type‐IV secretion system to translocate approximately 300 effector proteins into host cells, and the CpxRA two‐component system (TCS) was previously shown to regulate the expression of several of these effectors. In this study, we expanded the pool of L. pneumophila CpxR‐regulated genes to 38, including 27 effector‐encoding genes. Our study demonstrates...