Search results for: Bridgett M. vonHoldt

Items from 1 to 20 out of 22 results

article

Demographic history shapes North American gray wolf genomic diversity and informs species' conservation

Bridgett M. vonHoldt, Daniel R. Stahler, Kristin E. Brzeski, Marco Musiani, more

Effective population size estimates are critical information needed for evolutionary predictions and conservation decisions. This is particularly true for species with social factors that restrict access to breeding or experience repeated fluctuations in population size across generations. We investigated the genomic estimates of effective population size along with diversity, subdivision, and inbreeding...

article

Ear mite infection restructures otic microbial networks in conservation–reliant Santa Catalina Island foxes (Urocyon littoralis catalinae)

Jasmine Lu, Emily E. Hamblen, Lara J. Brenner, Julie L. King, more

Molecular Ecology > 32 > 4 > 892 - 903

Ceruminous gland tumours are highly prevalent in the ear canals of Santa Catalina Island foxes (Urocyon littoralis catalinae). Previous work suggests that tumours may result from a combination of ectoparasites, disruption of the host‐associated microbiome, and host immunopathology. More specifically, ear mite infection has been associated with broad‐scale microbial dysbiosis marked by secondary bacterial...

article

Persistence and expansion of cryptic endangered red wolf genomic ancestry along the American Gulf coast

Bridgett M. vonHoldt, Kristin E. Brzeski, Matthew L. Aardema, Christopher J. Schell, more

Molecular Ecology > 31 > 21 > 5440 - 5454

Admixture and introgression play a critical role in adaptation and genetic rescue that has only recently gained a deeper appreciation. Here, we explored the geographical and genomic landscape of cryptic ancestry of the endangered red wolf that persists within the genome of a ubiquitous sister taxon, the coyote, all while the red wolf has been extinct in the wild since the early 1980s. We assessed...

article

A sliver of the past: The decimation of the genetic diversity of the Mexican wolf

Ulrike H. Taron, Isabel Salado, Mariana Escobar‐Rodríguez, Michael V. Westbury, more

Molecular Ecology > 30 > 23 > 6340 - 6354

The endangered Mexican wolf (Canis lupus baileyi) is known to carry exceedingly low levels of genetic diversity. This could be (i) the result of long‐term evolutionary patterns as they exist at the southernmost limit of the species distribution at a relatively reduced effective size, or (ii) due to rapid population decline caused by human persecution over the last century. If the former, purifying...

article

Heritability of interpack aggression in a wild pedigreed population of North American grey wolves

Bridgett M. vonHoldt, Alexandra L. DeCandia, Elizabeth Heppenheimer, Ilana Janowitz‐Koch, more

Molecular Ecology > 29 > 10 > 1764 - 1775

Aggression is a quantitative trait deeply entwined with individual fitness. Mapping the genomic architecture underlying such traits is complicated by complex inheritance patterns, social structure, pedigree information and gene pleiotropy. Here, we leveraged the pedigree of a reintroduced population of grey wolves (Canis lupus) in Yellowstone National Park, Wyoming, USA, to examine the heritability...

article

Ear mite infection is associated with altered microbial communities in genetically depauperate Santa Catalina Island foxes (Urocyon littoralis catalinae)

Alexandra L. DeCandia, Lara J. Brenner, Julie L. King, Bridgett M. vonHoldt

Molecular Ecology > 29 > 8 > 1463 - 1475

The host‐associated microbiome is increasingly recognized as a critical player in health and immunity. Recent studies have shown that disruption of commensal microbial communities can contribute to disease pathogenesis and severity. Santa Catalina Island foxes (Urocyon littoralis catalinae) present a compelling system in which to examine microbial dynamics in wildlife due to their depauperate genomic...

article

Of microbes and mange: consistent changes in the skin microbiome of three canid species infected with Sarcoptes scabiei mites

Alexandra L. DeCandia, Kennedy N. Leverett, Bridgett M. vonHoldt

Parasites & Vectors > 2019 > 12 > 1 > 1-10

Background Sarcoptic mange is a highly contagious skin disease caused by the ectoparasitic mite Sarcoptes scabiei. Although it afflicts over 100 mammal species worldwide, sarcoptic mange remains a disease obscured by variability at the individual, population and species levels. Amid this variability, it is critical to identify consistent drivers of morbidity, particularly at the skin barrier. Methods...

article

Toward an integrative molecular approach to wildlife disease

Alexandra L. DeCandia, Andrew P. Dobson, Bridgett M. vonHoldt

Conservation Biology > 32 > 4 > 798 - 807

Pathogens pose serious threats to human health, agricultural investment, and biodiversity conservation through the emergence of zoonoses, spillover to domestic livestock, and epizootic outbreaks. As such, wildlife managers are often tasked with mitigating the negative effects of disease. Yet, parasites form a major component of biodiversity that often persist. This is due to logistical challenges...

article

Defense of an expanded historical range for the Mexican wolf: A comment on Heffelfinger et al.

Sarah A. Hendricks, Stephan Koblmüller, Ryan J. Harrigan, Jennifer A. Leonard, more

The Journal of Wildlife Management > 81 > 8 > 1331 - 1333

article

Admixture mapping identifies introgressed genomic regions in North American canids

Bridgett M. vonHoldt, Roland Kays, John P. Pollinger, Robert K. Wayne

Molecular Ecology > 25 > 11 > 2443 - 2453

Hybrid zones typically contain novel gene combinations that can be tested by natural selection in a unique genetic context. Parental haplotypes that increase fitness can introgress beyond the hybrid zone, into the range of parental species. We used the Affymetrix canine SNP genotyping array to identify genomic regions tagged by multiple ancestry informative markers that are more frequent in an admixed...

article

Genomic Flatlining in the Endangered Island Fox

Jacqueline A. Robinson, Diego Ortega-Del Vecchyo, Zhenxin Fan, Bernard Y. Kim, more

Current Biology > 2016 > 26 > 9 > 1183-1189

Genetic studies of rare and endangered species often focus on defining and preserving genetically distinct populations, especially those having unique adaptations [1, 2]. Much less attention is directed at understanding the landscape of deleterious variation, an insidious consequence of geographic isolation and the inefficiency of natural selection to eliminate harmful variants in small populations...

article

Epigenetics in ecology and evolution: what we know and what we need to know

Koen J. F. Verhoeven, Bridgett M. vonHoldt, Victoria L. Sork

Molecular Ecology > 25 > 8 > 1631 - 1638

article

The concerted impact of domestication and transposon insertions on methylation patterns between dogs and grey wolves

Ilana Janowitz Koch, Michelle M. Clark, Michael J. Thompson, Kerry A. Deere‐Machemer, more

Molecular Ecology > 25 > 8 > 1838 - 1855

The process of domestication can exert intense trait‐targeted selection on genes and regulatory regions. Specifically, rapid shifts in the structure and sequence of genomic regulatory elements could provide an explanation for the extensive, and sometimes extreme, variation in phenotypic traits observed in domesticated species. Here, we explored methylation differences from >24 000 cytosines distributed...

article

Genetic subdivision and candidate genes under selection in North American grey wolves

Rena M. Schweizer, Bridgett M. vonHoldt, Ryan Harrigan, James C. Knowles, more

Molecular Ecology > 25 > 1 > 380 - 402

Previous genetic studies of the highly mobile grey wolf (Canis lupus) found population structure that coincides with habitat and phenotype differences. We hypothesized that these ecologically distinct populations (ecotypes) should exhibit signatures of selection in genes related to morphology, coat colour and metabolism. To test these predictions, we quantified population structure related to habitat...

article

Identification of recent hybridization between gray wolves and domesticated dogs by SNP genotyping

Bridgett M. vonHoldt, John P. Pollinger, Dent A. Earl, Heidi G. Parker, more

Mammalian Genome > 2013 > 24 > 1-2 > 80-88

The ability to detect recent hybridization between dogs and wolves is important for conservation and legal actions, which often require accurate and rapid resolution of ancestry. The availability of a genetic test for dog–wolf hybrids would greatly support federal and legal enforcement efforts, particularly when the individual in question lacks prior ancestry information. We have developed a panel...

article

Breed-specific ancestry studies and genome-wide association analysis highlight an association between the MYH9 gene and heat tolerance in Alaskan sprint racing sled dogs

Heather J. Huson, Bridgett M. vonHoldt, Maud Rimbault, Alexandra M. Byers, more

Mammalian Genome > 2012 > 23 > 1-2 > 178-194

Alaskan sled dogs are a genetically distinct population shaped by generations of selective interbreeding with purebred dogs to create a group of high-performance athletes. As a result of selective breeding strategies, sled dogs present a unique opportunity to employ admixture-mapping techniques to investigate how breed composition and trait selection impact genomic structure. We used admixture mapping...

article

Evolutionary genomics of dog domestication

Robert K. Wayne, Bridgett M. vonHoldt

Mammalian Genome > 2012 > 23 > 1-2 > 3-18

We review the underlying principles and tools used in genomic studies of domestic dogs aimed at understanding the genetic changes that have occurred during domestication. We show that there are two principle modes of evolution within dogs. One primary mode that accounts for much of the remarkable diversity of dog breeds is the fixation of discrete mutations of large effect in individual lineages that...

article

STRUCTURE HARVESTER: a website and program for visualizing STRUCTURE output and implementing the Evanno method

Dent A. Earl, Bridgett M. vonHoldt

Conservation Genetics Resources > 2012 > 4 > 2 > 359-361

We present STRUCTURE HARVESTER (available at http://taylor0.biology.ucla.edu/structureHarvester/ ), a web-based program for collating results generated by the program STRUCTURE. The program provides a fast way to assess and visualize likelihood values across multiple values of K and hundreds of iterations for easier detection of the number of genetic groups that best fit the data. In addition, STRUCTURE...

article

Kin encounter rate and inbreeding avoidance in canids

ELI GEFFEN, MICHAEL KAM, REUVEN HEFNER, PALL HERSTEINSSON, more

Molecular Ecology > 20 > 24 > 5348 - 5358

Mating with close kin can lead to inbreeding depression through the expression of recessive deleterious alleles and loss of heterozygosity. Mate selection may be affected by kin encounter rate, and inbreeding avoidance may not be uniform but associated with age and social system. Specifically, selection for kin recognition and inbreeding avoidance may be more developed in species that live in family...

article

A novel assessment of population structure and gene flow in grey wolf populations of the Northern Rocky Mountains of the United States

BRIDGETT M. VONHOLDT, DANIEL R. STAHLER, EDWARD E. BANGS, DOUGLAS W. SMITH, more

Molecular Ecology > 19 > 20 > 4412 - 4427

The successful re‐introduction of grey wolves to the western United States is an impressive accomplishment for conservation science. However, the degree to which subpopulations are genetically structured and connected, along with the preservation of genetic variation, is an important concern for the continued viability of the metapopulation. We analysed DNA samples from 555 Northern Rocky Mountain...

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MICROBIOME (4)
ADMIXTURE (2)
ANCESTRY (2)
CANID (2)
CANIS LUPUS (2)
DYSBIOSIS (2)
EPIGENETICS (2)
GENOMICS (2)
GREY WOLF (2)
INTROGRESSION (2)
POPULATION GENETICS (2)
RADSEQ (2)
STAPHYLOCOCCUS PSEUDINTERMEDIUS (2)
ADAPTATION (1)
AGGRESSION (1)
BEHAVIOUR (1)
BISULFITE SEQUENCING (1)
BOTTLENECK (1)
CANIDS (1)
CARNIVORE (1)
CERUMINOUS GLAND TUMORS (1)
CHANNEL ISLAND FOXES (1)
CLUSTERING (1)
CONSERVATION (1)
CONSERVATION GENETICS (1)
CORYNEBACTERIUM (1)
COYOTES (1)
DISEASE (1)
DISPERSAL (1)
DNA METHYLATION (1)
DOMESTICATION (1)
EAR MITES (1)
ECOLOGICAL GENETICS (1)
EFFECTIVE POPULATION SIZE (1)
EPIGENÉTICA (1)
EVANNO METHOD (1)
GENETICS (1)
GENOME REGULATION (1)
GENÉTICA (1)
GRAY FOXES (1)
HERITABILITY (1)
HISTORICAL DNA (1)
HISTORICAL GENOME (1)
HOST–PARASITE (1)
INFLAMMATION (1)
KIN RECOGNITION (1)
LOCAL ADAPTATION (1)
MAMMAL (1)
MAMMALS (1)
MANEJO DE ENFERMEDADES DE FAUNA SILVESTRE (1)
METHYLATION (1)
MICROBIOMA (1)
MIGRANT DETECTION (1)
MIGRATION (1)
MITOCHONDRIA (1)
MS‐AFLP (1)
PHENOTYPIC PLASTICITY (1)
POPULATION ASSIGNMENT (1)
POPULATION STRUCTURE (1)
RAD‐SEQ (1)
RECOMBINATION (1)
RED FOXES (1)
RED WOLF (1)
SARCOPTES SCABIEI (1)
SARCOPTIC MANGE (1)
SECONDARY BACTERIAL INFECTION (1)
SEXUAL SELECTION (1)
SNP ARRAY (1)
STRUCTURE (1)
TRANSCRIPTOMICS (1)
TRANSCRIPTÓMICA (1)
TRANSGENERATIONAL INHERITANCE (1)
VISUALIZATION (1)
VULPES LAGOPUS (1)
WILDLIFE CONSERVATION (1)
WILDLIFE DISEASE MANAGEMENT (1)
X CHROMOSOME (1)
ZOONOSES (1)
ZOONOSIS (1)
人畜共患病 (1)
微生物组 (1)
表观遗传学 (1)
转录组学 (1)
遗传学 (1)
野生动物疫病管理 (1)
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Search results for: Bridgett M. vonHoldt

Demographic history shapes North American gray wolf genomic diversity and informs species' conservation

Ear mite infection restructures otic microbial networks in conservation–reliant Santa Catalina Island foxes (Urocyon littoralis catalinae)

Persistence and expansion of cryptic endangered red wolf genomic ancestry along the American Gulf coast

A sliver of the past: The decimation of the genetic diversity of the Mexican wolf

Heritability of interpack aggression in a wild pedigreed population of North American grey wolves

Ear mite infection is associated with altered microbial communities in genetically depauperate Santa Catalina Island foxes (Urocyon littoralis catalinae)

Of microbes and mange: consistent changes in the skin microbiome of three canid species infected with Sarcoptes scabiei mites

Toward an integrative molecular approach to wildlife disease

Defense of an expanded historical range for the Mexican wolf: A comment on Heffelfinger et al.

Admixture mapping identifies introgressed genomic regions in North American canids

Genomic Flatlining in the Endangered Island Fox

Epigenetics in ecology and evolution: what we know and what we need to know

The concerted impact of domestication and transposon insertions on methylation patterns between dogs and grey wolves

Genetic subdivision and candidate genes under selection in North American grey wolves

Identification of recent hybridization between gray wolves and domesticated dogs by SNP genotyping

Breed-specific ancestry studies and genome-wide association analysis highlight an association between the MYH9 gene and heat tolerance in Alaskan sprint racing sled dogs

Evolutionary genomics of dog domestication

STRUCTURE HARVESTER: a website and program for visualizing STRUCTURE output and implementing the Evanno method

Kin encounter rate and inbreeding avoidance in canids

A novel assessment of population structure and gene flow in grey wolf populations of the Northern Rocky Mountains of the United States

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