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Background
The THAP1 gene encodes a transcription factor, and pathogenic variants cause a form of autosomal dominant, isolated dystonia (DYT‐THAP1) with reduced penetrance. Factors underlying both reduced penetrance and the disease mechanism of DYT‐THAP1 are largely unknown.
Methods
We performed transcriptome analysis on 29 cortical neuronal precursors derived from human‐induced pluripotent stem...
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