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Aberrant activation of the Raf‐MEK‐ERK pathway has frequently been associated with various cancers, especially lung cancer. However, the key regulators of this pathway are largely unknown. Using functional proteomics screening, we found that KAP1 interacts with c‐Raf. Knocking out KAP1 decreased c‐Raf phosphorylation at serine 259 and increased its phosphorylation at serine 338, which activated MEK...