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Background & AimsThe idea of acute‐on‐chronic liver failure (ACLF) has emerged to identify those subjects with organ failure and high mortality rates. However, the absence of a precise definition has limited the clinical application and research related to the ACLF concept. We sought to validate the ACLF definition and the CLIF‐SOFA Score recently proposed by the EASL‐CLIF Consortium in a cohort...