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We evaluated the effects of genetic variation in toll‐like receptors (TLR), retinoic acid‐inducible gene I (RIG‐I) and their signalling pathways on spontaneous hepatitis C virus (HCV) resolution. We screened 95 single‐nucleotide polymorphisms (SNPs) in 22 genes. SNPs significantly associated with resolution in the discovery cohort were genotyped in a validation cohort. Multivariate logistic regression...
Summary. Twenty‐five per cent of individuals infected with hepatitis C virus (HCV) are able to clear HCV spontaneously. Differences in host genetics are believed to affect the outcome of HCV infection. We analysed an exonic, a promoter and an intronic single nucleotide polymorphism (SNP) of the interferon‐λ3 coding interleukin (IL)‐28B gene to study the relationship between IL28B SNPs and outcome...
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