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Objectives
This study was designed to demonstrate the potential of novel α‐lipoic acid–stearylamine (ALA‐SA) conjugate‐based solid lipid nanoparticles in modulating the pharmacokinetics and hepatotoxicity of tamoxifen (TMX).
Methods
α‐lipoic acid–stearylamine bioconjugate was synthesized via carbodiimide chemistry and used as a lipid moiety for the generation of TMX‐loaded solid lipid nanoparticles...