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Interleukin (IL)‐6−/− mice develop mature onset obesity, whereas i.c.v. injection of IL‐6 decreases obesity in rodents. Moreover, levels of IL‐6 in cerebrospinal fluid (CSF) were reported to be inversely correlated with obesity in humans. Tanycytes lining the base of the third ventricle (3V) in the hypothalamus have recently been reported to be of importance for metabolism. In the present study, we...
Interleukin (IL)‐1 and IL‐6 are immune modulating cytokines that also affect metabolic function because both IL‐1 receptor I deficient (IL‐1RI−/−) and IL‐6 deficient (IL‐6−/−) mice develop late‐onset obesity and leptin resistance. Both IL‐1 and IL‐6 appear to target the central nervous system (CNS) to increase energy expenditure. The hypothalamic arcuate nucleus (ARC) is a major relay between the...
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