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Chemical derivatization has been utilized in various forms of mass spectrometry for decades. For example, in gas chromatography‐mass spectrometry, derivatization has proven an essential tool that allows analysis of the less volatile components within a complex sample. Similarly, derivatization has been used to introduce a charge into specific components thereby enhancing their signal in electrospray...
Matrix‐assisted laser desorption/ionization mass spectrometry imaging (MALDI MSI) is a key tool for the analysis of biological tissues. It provides spatial and quantitative information about different types of analytes within tissue sections. Despite the increasing improvements of this technique, the low detection sensitivity of some compounds remains an important challenge to overcome. Poor sensitivity...
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