Search results for: Ann Hwang

Items from 1 to 11 out of 11 results

article

Joint AGS‐CCEHI Survey Offers Insights into Patient Engagement in Geriatric Clinical Settings

Ann Hwang, Gregg Warshaw

Journal of the American Geriatrics Society > 67 > 9 > 1791 - 1794

OBJECTIVES Many clinical practices and health systems are increasingly interested in adopting structures for consumer engagement to inform organizational policies and programs. These structures can include patient and family advisory committees, patient representation on an organization's board of directors, or inclusion of patients and family members in quality improvement activities. However, to...

article

Monoclonal Antibodies against Specific p53 Hotspot Mutants as Potential Tools for Precision Medicine

Le-Ann Hwang, Beng Hooi Phang, Oi Wah Liew, Jabed Iqbal, more

Cell Reports > 2018 > 22 > 1 > 299-312

The large number of mutations identified across all cancers represents an untapped reservoir of targets that can be useful for therapeutic targeting if highly selective, mutation-specific reagents are available. We report here our attempt to generate such reagents: monoclonal antibodies against the most common R175H, R248Q, and R273H hotspot mutants of the tumor suppressor p53. These antibodies recognize...

article

Innovations to more effectively engage patients and caregivers across the health care spectrum

Jeffrey T. Kullgren, Ann Hwang, Katy B. Kozhimannil

Healthcare > 2016 > 4 > 1 > 1-2

article

A His6-SUMO-eXact tag for producing human prepro-Urocortin 2 in Escherichia coli for raising monoclonal antibodies

Oi Wah Liew, Cui Xia Ang, Yu Pei Peh, Pek Ching Jenny Chong, more

Journal of Immunological Methods > 2014 > 403 > 1-2 > 37-51

This is a first report of recombinant production of human prepro-Urocortin 2 in Escherichia coli by N-terminal fusion with a triple His ₆ -SUMO-eXact tag and its subsequent use as an antigen for the production and screening of very high affinity monoclonal antibodies. The rationale for this combinatorial construct is that the His tag allows first step protein purification of insoluble and...

article

Purification and characterization of a thermostable keratinase from Meiothermus sp. I40

Jen-Min Kuo, Jing-Iong Yang, Wen-Ming Chen, Min-Hsiung Pan, more

International Biodeterioration & Biodegradation > 2012 > 70 > Complete > 111-116

Purification and characterization of keratinase from Meiothermus sp. I40, a newly identified strain isolated from hot springs, was carried out and reported. Crude enzyme was obtained from culture medium after incubation of I40 for 2 days and was purified by 20–80% precipitation with (NH ₄ ) ₂ SO ₄ , and separated by hydroxyapatite and Superdex pg 200 gel filtration chromatography...

article

Purification and Characterization of a Fish Scale-Degrading Enzyme from a Newly Identified Vogesella sp.

Min-Hsiung Pan, Mei-Ling Tsai, Wen-Ming Chen, Ann Hwang, more

Journal of Agricultural and Food Chemistry > 2010 > 58 > 23 > 12541 - 12546

article

Synthesis of UV-absorbing and fluorescent carrier ampholyte mixtures and their application for the determination of the operational pH values of buffering membranes used in isoelectric trapping separations

Robert North, Ann Hwang, Sanjiv Lalwani, Evan Shave, more

Journal of Chromatography A > 2006 > 1130 > 2 > 232-237

Success in isoelectric trapping separations critically depends on the knowledge of the accurate operational pH value of the buffering membranes used. Currently, due to a lack of easy, rapid, accurate methods that can be used for the post-synthesis determination of the operational pH value of a buffering membrane, only nominal pH values calculated from the amounts of the reagents used in the synthesis...

article

Mouse lymphomas caused by an intron-splicing donor site deletion of the FasL gene

Cheng-Chun Wang, Qi Zeng, Le-Ann Hwang, Ke Guo, more

Biochemical and Biophysical Research Communications > 2006 > 349 > 1 > 50-58

A spontaneous lymphoma was detected in mice, which was caused by a recessive autosomal mutation. The genetic basis was revealed to be a 5-bp deletion at the splicing donor site of the first intron of the FasL gene, resulting in aberrant transcripts coding for non-functional proteins. This mutation of the FasL gene caused development of lymphoma in all four mouse genetic backgrounds tested and the...

article

Lipoxygenase from Banana Leaf: Purification and Characterization of an Enzyme That Catalyzes Linoleic Acid Oxygenation at the 9-Position

Jen-Min Kuo, Ann Hwang, Dong-Bor Yeh, Min-Hsiung Pan, more

Journal of Agricultural and Food Chemistry > 2006 > 54 > 8 > 3151 - 3156

article

Induction of humoral and cellular responses in cynomolgus monkeys immunised with mannan-human MUC1 conjugates

Hilary A. Vaughan, Deborah W.M. Ho, Vaios A. Karanikas, Chin-Swee Ong, more

Vaccine > 1999 > 17 > 20-21 > 2740-2752

Mice immunised with oxidised mannan conjugated to the human mucin 1 (MUC1), produce MHC Class 1 restricted CD8 ⁺ cytotoxic T-cells which eradicate MUC1 ⁺ tumours, indicating potential for the immunotherapy of MUC1 ⁺ cancers in humans. We now describe preclinical studies performed in cynomolgus monkeys immunised with human or murine MUC1 conjugated to oxidised mannan, where...

article

Response of a Murine Vβ18-Alloreactive CTL Clone to Bacterial Superantigens

Le-Ann Hwang, Tr.K. Sabapathy, Kam M. Hui

Cellular Immunology > 1995 > 163 > 1 > 96-105

We have isolated, by limiting dilution, a murine anti-H-2K ^b T cell line derived from AKR/J mouse spleen cells following stimulation with H-2K ^b+ cells. This clone, designated 2AH10, has the phenotype H-2K ^k+ , CD8 ⁺ , LFA-1 ⁺ , ICAM-1 ⁺ , and 1L-2R ⁺ and, as determined by DNA-sequencing reactions, expresses the Vβ18 T cell receptor gene segment...

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Search results for: Ann Hwang

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