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The interaction of sodium hypochlorite (NaOCl) and chlorhexidine gluconate (CHX) produces an orange‐brown precipitate. The present study evaluated the influence of distilled water (H2O) in different irrigation protocols designed to prevent the formation of precipitate with NaOCl and CHX. Fifty canine teeth were instrumented and split longitudinally. The canal was examined with a stereomicroscope...