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Tumor cells in extramammary Paget’s disease sometimes overexpress human epidermal growth factor receptor 2 (HER2). Several case reports indicated successful response to HER2 inhibitor in patients with HER2‐positive metastatic extramammary Paget’s disease. However, these were single‐case reports, and most cases were evaluated only by immunohistochemistry and treated with HER2 inhibitor monotherapy...
Leptomeningeal melanomatosis is an extremely rare variant of primary central nervous system (CNS) melanoma and has a poor prognosis and no standard treatment. Primary CNS melanoma is derived from the melanocytes of the leptomeninges. Here, we describe a case of a 37-year-old male who visited our hospital due to worsening headaches. Characteristic imaging findings of this tumor type include hyper-dense...
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