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Magnetic nanoparticles (MNP) are intensely scrutinized for biomedical applications due to their excellent biocompatibility and adjustable magnetic field (MF) responsiveness. Three‐dimensional spheroid culture of ADSC improves stem cell proliferation and differentiation, increasing their potential for clinical applications. In this study we aimed to detect if MF levitated culture of ADSC loaded with...
Background The adipocyte expansion is a critical process with implications in the pathogenesis of obesity associated metabolic syndrome. Impaired adipogenesis leads to dysfunctional, hypertrophic adipocytes, local inflammation and peripheric insulin resistance. Methods We assessed the relationship between the adipogenic differentiation capacity of the subcutaneous adipose derived stem cells (ASCs),...
Despite multiple methods of treatment and a wealth of research in the field of regenerative medicine focusing on cartilage defects, the management of cartilage injuries remains a challenge. A recent study by Van Pham and colleagues proposes a method for preconditioning autologous adipose-derived stem cells. Their study offers evidence about the increased proliferative and chondrogenetic capabilities...
Breakthroughs in technology that deliver fast and accurate molecular biology data, together with the use of advanced software, and analytical methods made possible quantitative accumulation of biological information leading to a qualitative evolution. Sequencing of human genome was of the first door to the era of systemic understanding in life sciences. The paper reviews the emerging concepts of systems...
Research focused in detecting cause and progression of the diseases is gathering an impressive amount of data. Integrating available information in a systemic approach requires knowledge about details as well as overview about predictable interconnections. The amount of accumulated data often underscores human mind capabilities to perceiving links and correlations. The paper offers an overview about...
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