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Background
As childhood obesity prevalence increases, determining which patients respond to anti‐obesity medications would strengthen personalized approaches to obesity treatment. In the SCALE Teens trial among pubertal adolescents with obesity (NCT02918279), liraglutide 3.0 mg (or maximum tolerated dose) significantly reduced body mass index (BMI) standard deviation score on average versus placebo...
Objective
This study sought to evaluate the effect of 52 weeks of exenatide extended release (XR) on the maintenance of meal replacement therapy (MRT)‐induced BMI reduction in adolescents with severe obesity.
Methods
In this randomized, double‐blind, placebo‐controlled trial, 100 participants aged 12 to 18 years with BMI ≥ 1.2 × 95th percentile were enrolled in a short‐term MRT run‐in phase. Those...
Background
Weight loss in children and adolescents with type 2 diabetes (T2D) is associated with improved glycaemic control.
Objectives
To assess the effects of liraglutide vs placebo on body mass index (BMI) and weight parameters in children and adolescents with T2D using data from the ellipse trial (NCT01541215).
Methods
The ellipse trial randomized participants (10‐<17 years old, BMI >85th...
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