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Background Estrogen receptor alpha ( ERa/ESR1 ) expression is regulated by alternative splicing. Its most frequently detectable exon7 skipping isoform ( ERaD7 ) is a dominant negative variant. Elevated expression of ERaD7 was already detected in endometrial cancer (EC), while its potential prognostic significance has not been characterized so far. Exon7...
HnRNP G is a member of heterogeneous nuclear ribonucleoprotein (hnRNP) family with potent tumor suppressive activities. Human transformer‐2‐beta1 (hTra2‐beta1) belongs to the arginine‐serine rich like proteins and is found over‐expressed in various human cancers. It was recently shown that hnRNP G and hTra2‐beta1 exert antagonistic effects on alternative splicing. In our study we explored the impact...
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